FIGURE

Fig. 5

ID

ZDB-FIG-231130-20

Publication

Landi et al., 2023 - An in vivo functional assay to characterize human STAT5B genetic variants during zebrafish development

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Fig. 5

Effect of co-injecting p.Gln474Arg together with WT STAT5B mRNA in a 1:1 ratio in zebrafish embryos. (A) Statistical analysis of body length in embryos overexpressing WT, p.Gln474Arg and p.Gln474Arg/WT STAT5B mRNA. (B) Statistical analysis of pericardial edema, cyclopia and bent spine score in embryos overexpressing WT, p.Gln474Arg and p.Gln474Arg/WT STAT5B mRNA. (C) Percentage of embryos showing pericardial edema, cyclopia and bent spine in embryos overexpressing WT, p.Gln474Arg and p.Gln474Arg/WT STAT5B mRNA. Embryos were scored at 72 hpf and classified into three groups according to the severity of the malformation (1 = normal, 2 = mild, and 3 = severe. Mann–Whitney test, ***P < 0.0001, *P < 0.05, ns = not significant, P > 0.05. N = number of embryos. mm = millimeters.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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