FIGURE

FIGURE 4

ID

ZDB-FIG-231004-33

Publication

Zhao et al., 2023 - The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors

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FIGURE 4

Specific PLL neuromasts hair cells defects in pin1 morphants. (A–F) Co-injection of pin1 MO with p53 MO results in slight developmental delay and defective neuromasts hair cells formation in zebrafish embryos. Arrows in (C) indicate posterior neuromasts. (G–I) Analysis of neuromasts cells in pin1 MO/p53 MO injected ET4 embryos. Arrows in (G, H) indicate neuromasts hair cells along the PLL. (J–L) Analysis of mantle cells in pin1 MO/p53 MO injected ET20 embryos. Arrowheads in (J–L) indicate neuromasts mantle cells. (M–P) Analysis of hair cells and mantle cells in 48 hpf and 72 hpf double transgenic (ET4x20) embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-pin1 + MO4-tp53 sqet4Et + MO3-pin1 + MO4-tp53 sqet20Et + MO3-pin1 + MO4-tp53 sqet20Et; sqet4Et + MO3-pin1 + MO4-tp53
Knockdown Reagents:	MO3-pin1 MO4-tp53
Observed In:	neuromast hair cell neuromast mantle cell whole organism developmental growth
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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