FIGURE

Figure 6

ID
ZDB-FIG-231002-441
Publication
Karolczak et al., 2023 - Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
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Figure 6

Altered recycling endosomal trafficking in mtm livers.

Confocal images of 7 dpf zebrafish sections immunostained for Mdr1 (purple) and Rab11 (green), shown at lower and higher magnification. Mdr1 is a canalicular transporter, and Rab11 is a GTPase found on recycling endosomes. (A) Rab11 clustered around the canaliculi in WT larvae. (B) In mtm larvae, Rab11 localization was more diffuse throughout the cytoplasm. Scale bars: 10 μm (zoom view of the images above, ×2.3).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.