FIGURE

Fig. 6

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ZDB-FIG-231002-209

Publication

Riesle et al., 2023 - Activator-blocker model of transcriptional regulation by pioneer-like factors

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Fig. 6

Zygotic gene expression is balanced by synergy and competition of Pou5f3 and Nanog on common enhancers.

a Schemes of six alternative mini-model groups for direct target regulation by Pou5f3, Nanog and SoxB1. bfoxb1a and tbx5a transcripts dynamics fitted best to the antagonistic groups 2b. P + N- and 3b. P-N+ respectively. c Heatmap of zygotic genes, downregulated in MZtriple, sorted by best fit to one of the six model groups. d–f Two-sided χ² tests, positive correlations between the transcriptomics and genomics groups are shown in blue and negative in red. Exact p-values: p = 4.292e-64 (d), p = 3.128e-77 (e), p = 4.314e-79 (f). Vertical axis: transcriptomics groups. Direct enhancers linked to the promoters of zygotic genes were sorted by best fit transcriptional model. Synergistic and antagonistic model groups are boxed. Horizontal axis: direct enhancers were sorted by chromatin accessibility, and by H3K27ac regulation by sum of PSN activities (d), by Pou5f3 (e), or by Nanog (f). *- data from⁵. Source data are provided as a Source Data file 2 (a-c) and Source Data file 3 (d–f).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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