FIGURE

Fig. 4

ID

ZDB-FIG-230929-7

Publication

Nasiri Sovari et al., 2023 - Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2'-bipyridine rhenium tricarbonyl complexes

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Fig. 4

Anticancer activity of selected complexes against highly metastatic human HCT-116 cells in zebrafish xenografts. Tg(-2.8fabp10a:EGFP) xenografts (n = 20) were exposed to complexes at 10 μM doses, and then analysed after 3-day treatments for tumour progression and metastasis. Representative fluorescent microscopy images are shown (A); white solid arrow indicates treatment-affected liver (hepatotoxicity). Only applied treatments of complexes 4 and 7 markedly reduced the tumour growth, compared to those in the control group (B). Data are normalized in relation to the control group (B and C). *P < 0.05; **P < 0.01; ***P < 0.001.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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