FIGURE SUMMARY
Title

Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2'-bipyridine rhenium tricarbonyl complexes

Authors
Nasiri Sovari, S., Kolly, I., Schindler, K., Djuric, A., Srdic-Rajic, T., Crochet, A., Pavic, A., Zobi, F.
Source
Full text @ Dalton Trans.
Fig. 1

Crystal structures of compounds 2, 3 and 5. Thermal ellipsoids are at 30% probability. Hydrogen atoms are omitted for clarity.

Fig. 2

Crystal structures of compounds 6, 7, 9 and 10. Thermal ellipsoids are at 30% probability. Hydrogen atoms are omitted for clarity.

Fig. 3

Anticancer activity of selected complexes against human Panc-1 cells in zebrafish xenografts. Tg(fli1:EGFP) xenografts (n = 20) were exposed to complexes at 8 μM doses, and then analysed after 3-days treatments for tumour progression and metastasis. Representative fluorescent microscopy images are shown (A); white solid arrows indicate disseminated cells. Only applied treatments of complexes 6 and 7 markedly reduced the tumour, growth compared to those in the control group (B). Data are normalized in relation to the control group (B). *P < 0.05; **P < 0.01; ***P < 0.001.

Fig. 4

Anticancer activity of selected complexes against highly metastatic human HCT-116 cells in zebrafish xenografts. Tg(-2.8fabp10a:EGFP) xenografts (n = 20) were exposed to complexes at 10 μM doses, and then analysed after 3-day treatments for tumour progression and metastasis. Representative fluorescent microscopy images are shown (A); white solid arrow indicates treatment-affected liver (hepatotoxicity). Only applied treatments of complexes 4 and 7 markedly reduced the tumour growth, compared to those in the control group (B). Data are normalized in relation to the control group (B and C). *P < 0.05; **P < 0.01; ***P < 0.001.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dalton Trans.
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