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ZDB-FIG-230915-9

Publication

Wang et al., 2023 - Synergistic anti-cancer and attenuation effects of thymosin on chemotherapeutic drug vinorelbine in tumor-bearing zebrafish

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Fig. 1

Fig. 1. Thymosin synergizes with vinorelbine to inhibit human lung cancer A549 cells in the xenotransplanted zebrafish model. (A) Schematic diagram and grouping of our experiments. CM-DiI-labeled human lung cancer A549 cells are injected into the yolk sac of 2 dpf zebrafish to establish the xenotransplanted zebrafish model. The experimental groupings and their corresponding color markers are shown in the figure. (B) Representative images of xenotransplanted zebrafish in different groups. The dotted box indicates the yolk sac of the zebrafish. Scale bar, 100 µm. (C) Fluorescence intensity of CM-DiI-labeled A549 cells after treatment of vinorelbine and thymosin for 18 h. (D) The synergistic anti-cancer effect of thymosin on vinorelbine. Data are expressed as mean ± SEM. n = 10. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. Abbreviations: dpf: days post fertilization; MTC: maximum tolerable concentration; T: thymosin; V: vinorelbine.

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