FIGURE

Figure 7

ID

ZDB-FIG-230731-110

Publication

Cannone et al., 2023 - Human Mutated MYOT and CRYAB Genes Cause a Myopathic Phenotype in Zebrafish

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Figure 7

Transmission electron micrographs of no-injected (A,B) or injected with vehicle (C,D), hMYOT WT (E,F), hCRYAB WT (G,H), hMYOT S95I (I,J), hCRYAB G154S (K,L). In non-injected wildtype embryos or injected embryos with vehicle or wildtype genes muscle fibers show normal sarcomere structure with highly organized and well-aligned thick and thin myofilaments flanked by Z-disks. By contrast, embryos injected with hMYOT S95I sarcomeres showed abnormalities of Z-disk (black arrowheads in panel (J)), which appears irregular with its extension into I band. Large areas depleted of myofilaments, stressed fiber-like structures (black asterisk in panel (K)) and reduced density of the sarcomeric myofilaments were observed in myofibers of hCRYAB G154S injected embryos. Scale bar, 200 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.