FIGURE

Fig. 2

ID

ZDB-FIG-230714-44

Publication

Zhang et al., 2023 - Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues

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Fig. 2

Fig. 2. TCC reduces the joint space of the zebrafish anal fin. (A) Scheme of Alcian blue and alizarin red staining of zebrafish treated with TCC. Zebrafish were treated with 3 μM TCC or and equal concentration of DMSO (0.025 %, V/V) as a control for three weeks before staining. (B) Typical images of the zebrafish anal fin with Alcian blue and alizarin red staining reveal that TCC reduces the joint space of the zebrafish anal fin. The intraarticular space was quantified by the virtual ruler in the imaging system, which was precalibrated by a physical ruler. (C) Quantification of the joint space of the zebrafish anal fin treated with 3 μM TCC or an equal concentration of DMSO (0.025 %, V/V). * ** * refers to P < 0.0001 and n = 12.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2
Condition:	chemical treatment by environment: triclocarban
Observed In:	anal fin skeleton joint
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Journal of hazardous materials, 447, Zhang, Y., He, L., Yang, Y., Cao, J., Su, Z., Zhang, B., Guo, H., Wang, Z., Zhang, P., Xie, J., Li, J., Ye, J., Zha, Z., Yu, H., Hong, A., Chen, X., Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues, 130747130747, Copyright (2023) with permission from Elsevier. Full text @ J. Hazard. Mater.