FIGURE

Fig. 1

ID

ZDB-FIG-230703-2

Publication

Kareklas et al., 2023 - Autism-associated gene shank3 is necessary for social contagion in zebrafish

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Fig. 1

Characterization of the genetic mutation of shank3a and its effects on protein transcription and shank3a expression. (a) The shank3a paralogue is found on chromosome 18, where mutation to Exon 2 precedes the localisation of the four typical SHANK3 domains, ankyrin repeats (ANK), SRC Homology 3 (SH3), PDZ and sterile α motif (SAM). (b) The genetic mutation induced in our study included a five base pair deletion that elicits (c) transcription of a markedly truncated protein structure and (d) significant decreases in shank3a expression

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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