FIGURE

Fig 1

ID

ZDB-FIG-230621-37

Publication

Martinez et al., 2020 - Stimulation of the human mitochondrial transporter ABCB10 by zinc-mesoporphrin

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Fig 1

Heme synthesis pathway and structures of porphyrins.

(A) Heme synthesis occurs through eight reactions that take place between the mitochondrial matrix and the cytoplasm. The first step is the formation of delta-aminolevulinic acid (ALA, structure shown in the left top corner), which is then exported to the cytoplasm through a yet unidentified mechanism. ABCB10 can form a complex with ferrochelatase (FECH) and mitoferrin (Mtfn). Once synthesized, heme is exported by an unidentified protein. (B) Structure of heme (Fe²⁺ protoporphyrin). (C) Structure of hemin (Fe³⁺-Cl protoporphyrin). Commercially available heme comes in the form of hemin since in free heme the iron can be quickly oxidized. (D) Structure of Zn²⁺-protoporphyrin. (E) Structure of Zn²⁺-mesoporphyrin; notice the presence of ethyl instead of vinyl groups in the porphyrin ring. All chemical structures were created in ChemDraw.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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