FIGURE

Fig. 4

ID

ZDB-FIG-230619-11

Publication

Groenewoud et al., 2023 - Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target

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Fig. 4

Ferroptosis-related genes negatively correlate with uveal melanoma patient survival.

A, Analysis of the UM-specific survival in both LUMC and TCGA patient cohorts. B, C High GPX4 (B) and SLC7A11 (C) expression levels (divided over the median) show a correlation with reduced patient survival (p = 0.004 and p = 0.0014, respectively). D, E Comparative analysis of the relation between GPX4 (D) and SLC7A11 (E) and survival in BAP1⁺ (LUMC, determined by IHC, n = 25) and BAP1 high (TCGA, determined by RNAseq, n = 40) UM samples compared to survival in BAP1^- (LUMC, IHC, n = 31) and BAP1 low (TCGA, RNAseq, n = 40) UM samples. The expression levels of GPX4, SLC7A11 and BAP1 were split at the median, and curves were plotted using SPSS.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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