FIGURE

Figure 2

ID

ZDB-FIG-230523-45

Publication

Silva et al., 2023 - In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity

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Figure 2

Compromised number and distribution of HuC/D neurons in MCT8MO embryos at specific stages of development. (A) Representative maximum projection images of the pan-neuronal marker HuC/D immunostaining (white) in the spinal cord between somite 8-12. Comparison of the pattern of neuron distribution in the spinal cord between CTRLMO and MCT8MO embryos at different stages of development. Red highlight - dorsal views, anterior spinal cord up. Blue highlight - lateral view, anterior spinal cord right. Green highlight -transversal view, dorsal spinal cord up. Scale bars represent 25 µm. (B) Quantification of the number of HuC/D single positive cells in a 2-myotome length of the spinal cord. n=9-17. CTRL (CTRLMO); MO (MCT8MO). Results are presented as mean ± SD; Statistical significance determined by t-test: two-sample, assuming equal variances: *p<0.05; ***p<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)