FIGURE

Figure S3.

ID

ZDB-FIG-230523-27

Publication

Cevik et al., 2023 - WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium

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Figure S3.

Rescue of dye uptake defects by ELMD-1 or RPI-2.

(A) Shown are representative schematics of human and C. elegans WDR-31/WDR31. Human WDR31 (NP_660284.1) has four WD domains, whereas C. elegans WDR-31 (NP_494344.1) has three WD domains (https://prosite.expasy.org/; [Sigrist et al, 2013]). (B) Schematic diagrams of wdr-31, elmd-1, and rpi-2 together with corresponding deletions are shown. Scale bars: 250 bp. (C, D) Fluorescence microscope images of mutant worms (head and tail) with red-fluorescent dye uptake (Texas red filter) and GFP-tagged ELMD-1 and RPI-2 (fluorescence filter set for GFP) are shown. The head or tail in the dotted lines is indicated by numbers in the combined fluorescence images. GFP expression in combination with RED fluorescence indicates the rescue of dye uptake defects.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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