FIGURE

Fig. 1

ID

ZDB-FIG-230522-1

Publication

Dam et al., 2022 - Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases

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Fig. 1

In vitro profile of TriSLas against replicating H37Rv (a–c) and nonreplicating ss18b (d). The bactericidal activity of (a) 11, (b) 12, and (c) bedaquiline was measured by cfu counting following 1 or 2 weeks of incubation with 1× MIC (filled circles, solid line), 2× MIC (filled triangles, dashed line), or 4× MIC (filled squares, dotted line). Data are mean and SEM of at least three independent biological replicates, and statistical analysis was performed with a paired t-test. (d) Bactericidal activity following 1-week incubation with TriSLAs and control antibiotics (isoniazid (INH) bedaquiline (BDQ), rifampicin (RIF)) against nonreplication ss18b-lux as measured by cfu counting. Data are mean and SEM of at least three independent biological replicates, and the statistical test to compare compound exposure to no compound control was performed using a two-tailed unpaired t test with Welch’s correction. The time-dependent decrease in ss18b-lux luminescence is available in Figure S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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