FIGURE

Fig. 6

ID

ZDB-FIG-230517-12

Publication

Kayser et al., 2022 - Clock genes rescue nphp mutations in zebrafish

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Fig. 6

Susceptibility of nphp mutants in response to depletion of additional nphp genes. (A) Zebrafish nphp4^sa41188 (+/+) siblings developed glomerular cysts and cloaca malformation (asterisks) after depletion of nphp8 with TBM (0.2 mm). (B) While the nphp4^sa41188 in-cross (F2 generation) (m/m) was viable and displayed very little ciliopathy-specific phenotypes, additional depletion of nphp8 with TBM (0.2 mm) increased the frequency of glomerular cysts and cloaca malformation in comparison with nphp4^sa41188 (+/+) siblings. (C) Zebrafish nphp8^sa24730 (m/m) developed glomerular cysts and cloaca malformations (asterisks) after depletion of nphp4 with TBM (0.2 mm). (D) The nphp8^sa24730 in-cross (F2 generation) (m/m) was viable and displayed very little ciliopathy-specific phenotypes. Additional depletion of nphp4 with TBM (0.2 mm) slightly increased the frequency of glomerular cysts, but had little effect on cloaca malformation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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