ZFIN Image: Kayser et al., 2022, Fig. 6

Image

Figure Caption

Fig. 6 Susceptibility of nphp mutants in response to depletion of additional nphp genes. (A) Zebrafish nphp4^sa41188 (+/+) siblings developed glomerular cysts and cloaca malformation (asterisks) after depletion of nphp8 with TBM (0.2 mm). (B) While the nphp4^sa41188 in-cross (F2 generation) (m/m) was viable and displayed very little ciliopathy-specific phenotypes, additional depletion of nphp8 with TBM (0.2 mm) increased the frequency of glomerular cysts and cloaca malformation in comparison with nphp4^sa41188 (+/+) siblings. (C) Zebrafish nphp8^sa24730 (m/m) developed glomerular cysts and cloaca malformations (asterisks) after depletion of nphp4 with TBM (0.2 mm). (D) The nphp8^sa24730 in-cross (F2 generation) (m/m) was viable and displayed very little ciliopathy-specific phenotypes. Additional depletion of nphp4 with TBM (0.2 mm) slightly increased the frequency of glomerular cysts, but had little effect on cloaca malformation.

Acknowledgments

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