Figure 2

Excitatory V2a subtypes in zebrafish and mice. (A) In zebrafish, the V2a class (pink) is divided into fast (light gray, outline), medium (medium gray, outline) and slow (dark gray, outline) subtypes. The fast subtypes are more dorsal than the slow subtypes. Each subtype receives reticulospinal and sensory input, and projects to the corresponding fast, medium or slow class of motor (green) and V0d (light blue) neurons. Zebrafish also have a cholinergic subclass of V2a neurons, which receive input from Mauthner cells and have bidirectional connections to fast motor neurons. (B) In mice, the V2a population receives descending and sensory input, projects to inhibitory V0d and motor neurons, and has recurrent connections. Mouse V2a neurons subdivide into type I and type II, which further divide into medial and lateral subtypes (shades of blue, outlines). Type I V2a neurons connect to V0 neurons (V0d in light blue and V0v in dark blue); type II V2a neurons have ascending connections.