Fig. 5
- ID
- ZDB-FIG-230510-10
- Publication
- Economou et al., 2022 - Nodal signaling establishes a competency window for stochastic cell fate switching
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Switching to an endodermal fate is not associated with suppression of mesodermal fate (A) Left: uniform manifold approximation and projection (UMAP) visualization of gata5-positive cells derived from 50% epiboly stage embryos. Blue cells are those expressing at least one read count for sox32. Right: stacked bar plot showing the pct (percentage of expressing cells) for the top 10 genes differentially expressed in sox32-positive cells (magenta) compared to the pct for the same genes in sox32-negative cells (green). (B) Left: as in (A), but blue cells are those expressing less than one read count for sox32. Right: stacked bar plot showing the pct for the top 10 genes differentially expressed in sox32-negative cells (green) compared to the pct for the same genes in sox32-positive cells (magenta). (C) UMAP visualization of gata5-positive cells at 50% epiboly. Cells were clustered with increasing granularity across five iterations, Find cluster resolution = 0.1 to 0.5. Color coding refers to the different clusters. (D) As in (A), but for 60% epiboly embryos. (E) As in (B), but for 60% epiboly embryos. (F) As in (C), but for 60% epiboly embryos, Find cluster resolution = 0.01 to 0.5. See also Figures S5 and S6. |
Reprinted from Developmental Cell, 57, Economou, A.D., Guglielmi, L., East, P., Hill, C.S., Nodal signaling establishes a competency window for stochastic cell fate switching, 26042622.e52604-2622.e5, Copyright (2022) with permission from Elsevier. Full text @ Dev. Cell