FIGURE

FIGURE 5

ID

ZDB-FIG-230429-5

Publication

Vedder et al., 2023 - pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens

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FIGURE 5

Morphology of treated zebrafish 2 dpf. An overview of the gross phenotypes of treated zebrafish 2 days post-fertilization. All compounds were dissolved in DMSO; therefore, DMSO served as the negative control. NaCl served as the salt control. The effects of atorvastatin treatment on zebrafish embryos were previously established; thus, this drug was used as a positive control for cardioactivity. The aquatic toxic compound enilconazole was used as the toxic positive control. Heart morphology was drastically affected only by enilconazole, cycloheximide, and pregnenolone. The black arrow in the image of iopanoic acid-treated zebrafish embryo indicates caudal fin deformity. The scale bar indicates 500 µm in overview brightfield images and 150 µm in fluorescence images. (a) Atrium; (v) ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol