FIGURE

Figure 2

ID

ZDB-FIG-230331-88

Publication

Pardo-S�nchez et al., 2023 - Dual Role of DUOX1-Derived Reactive Oxygen Species in Melanoma

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Figure 2

Melanocyte DUOX1 inhibition does not affect melanocyte transformation and early melanoma progression. (A) Schematic representation of the procedure to co-express oncogenic NRAS-Q61R and DN-DUOX1 in melanocytes. Zebrafish one-cell Casper zebrafish embryos were injected with MinicoopR mitfa:NRAS-Q61R and either MinicoopR mitfa:DN-DUOX1 or MinicoopR mitfa:EGFP (control). Larvae were examined at 5 dpf for the presence of melanocytes and images were acquired monthly for 3 months to track melanoma development. (B) Representative images of the five different categories established to classify tumor progression. (C) Percentages of fish in the different categories at 30, 60, 75 and 90 dpf. (D) Tumor free curve. Representation of the percentage of fish without nodular tumors.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)