ZFIN Image: Pardo-S�nchez et al., 2023, Figure 2

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Figure Caption

Figure 2

Melanocyte DUOX1 inhibition does not affect melanocyte transformation and early melanoma progression. (A) Schematic representation of the procedure to co-express oncogenic NRAS-Q61R and DN-DUOX1 in melanocytes. Zebrafish one-cell Casper zebrafish embryos were injected with MinicoopR mitfa:NRAS-Q61R and either MinicoopR mitfa:DN-DUOX1 or MinicoopR mitfa:EGFP (control). Larvae were examined at 5 dpf for the presence of melanocytes and images were acquired monthly for 3 months to track melanoma development. (B) Representative images of the five different categories established to classify tumor progression. (C) Percentages of fish in the different categories at 30, 60, 75 and 90 dpf. (D) Tumor free curve. Representation of the percentage of fish without nodular tumors.

Acknowledgments

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