FIGURE 1

Foxe1 protein structure in human, mouse and zebrafish. Multiple sequence alignment of full-length human, mouse and zebrafish FOXE1 protein. The protein contains three characterized domains which are annotated with colored lines. The similarity of the Forkhead domain (FHD) is 97% and 100%, respectively, between zebrafish and humans and between mouse and human. The sequence similarity of the whole protein between human and zebrafish is 54%. NLS is 100% identical between all species and the poly alanine stretch (PAS) is only present in humans and mouse. Red boxes mark the putative DNA-binding residues and asterisks (*) mark locations of missense mutations that were reported in individuals with Bamforth–Lazarus syndrome (Clifton-Bligh et al., 1998; Castanet et al., 2002; Baris et al., 2006; Castanet and Polak 2010; Carre et al., 2014; Sarma et al., 2022). NLS: nuclear localization signal, FHD: forkhead box domain PAS: poly alanine stretch in human and mouse FOXE1. Alignment made using Clustal Omega.