FIGURE

Figure 3

ID

ZDB-FIG-230228-273

Publication

Lin et al., 2023 - AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish

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Figure 3

The sequence and potential response elements in the 4.7 kb agrp promoter of zebrafish. The nucleotide sequence was downloaded from the Ensembl website ?https://asia.ensembl.org/Danio_rerio/Info/Index" (accessed on 2 May 2022). (A) The translational start codon (ATG) is underlined and shown as position +1. Nucleotides are numbered on the right, starting with the translational codon. Potential binding motifs in the proximal region are also marked. (B) Sequences of the putative agrp regulatory element. The predicted binding motif within a distal region of agrp promoter. Potential binding motifs are marked. (C) Hypothetical model of agrp transcription activation in zebrafish. The proteins shown in the figure are: TATA-box-binding protein (Tbp), CCAAT/enhancer-binding protein alpha (Cebp?), ISL LIM homeobox 1 (Isl1), Kruppel-like factor 4 (Klf4), nuclear receptor subfamily 3 group C member 1 (Nr3c1), forkhead box O1 (Foxo1), GATA-binding protein 1 (Gata1), T cell acute lymphocytic leukemia 1 (Tal1), and brain-specific homeobox (Bsx).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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