FIGURE

Fig. 6

ID

ZDB-FIG-230226-11

Publication

Montnach et al., 2022 - In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

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Fig. 6

In vivo uncaging of HwTxIV-Nvoc.

a Representative trajectory plots of mice injected with vehicle (left), non-caged HwTxIV (center) or HwTxIV-Nvoc (right). b–c Quantification of total movements (b) and rearing (c) in mice injected with vehicle (white circles), HwTxIV (black circles) or HwTxIV-Nvoc (orange circles). (n = 5 in each group, mean ± SEM *p < 0.05; **p < 0.01; ***p < 0.001 versus vehicle, two-sided repeated-measures 2-way ANOVA test followed by Tukey’s post test). d Representative twitches obtained from mice injected with vehicle or HwTxIV-Nvoc at t = 0; t = 5; t = 10; t = 15; t = 20 min after injection. e EDL twitch force normalized to muscle mass (g/mg of EDL) in vehicle or HwTxIV-Nvoc mice before and after illumination (365 nm, 50 mW/cm²). (n = 5 in each group, mean ± SEM **p = 0.0041; ***p = 0.0002 versus t0, two-sided repeated-measures Friedman test followed by Dunn’s post-test). Source data are provided as a Source Data File.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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