FIGURE

Figure 1

ID

ZDB-FIG-230217-48

Publication

Kowald et al., 2023 - Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

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Figure 1

Toxicity of BCG-Medac is caused by a soluble component of the powder. (A) Light micrograph image of 5-day-old zebrafish larvae three days after having received a subcutaneous injection of ~3 nL of completely reconstituted BCG-Medac. (B) Quantification of larval survival at 5 days post-fertilization, three days after subcutaneous injection of ~3 nL of completely reconstituted BCG-Medac, or only PBS (vehicle). (C) Graph showing the proportion of larvae that survived at 5 days post-fertilization, three days after injection with the indicated concentrations of 3 nL of completely reconstituted BCG-Medac. (D,E) Light micrograph images of 5-day-old zebrafish larvae three days after having received a subcutaneous injection of ~3 nL of pelleted and re-suspended bacteria (D) or supernatant (E) from the reconstituted BCG-Medac powder. (F) Graph showing the proportion of larvae that survived at 5 days post-fertilization, three days after injection with ~3 nL of pelleted, and re-suspended bacteria (blue line) or supernatant (orange line) from the reconstituted BCG-Medac powder. n = 15 embryos per group. *: p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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