FIGURE

Fig. 1

ID

ZDB-FIG-230217-188

Publication

Guo et al., 2023 - Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis

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Fig. 1

Zebrafish larva glucocorticoid-induced osteoporosis model.

a The flowchart demonstrates the process of establishing a zebrafish osteoporosis model. Zebrafish larvae (n = 20) were exposed to 10 µM dexamethasone (DEX) from D3 to D7. b Fluorescence images in each of the osteoporotic zebrafish labeled with sp7 from D3 to D7 after the addition of DEX. Scale bars: 1 mm. c Alizarin red staining images in each of the osteoporotic zebrafish from D3 to D7 after the addition of DEX. Scale bars: 1 mm. d, e Semiquantitative analysis of the mineralized area and integrated optical density (IOD) at 7 days post-fertilization (dpf). f Gene set enrichment analysis (GSEA) of the osteoblastic (upper panel)/osteoclastic (bottom panel) differentiation signature was performed from the transcriptomes of the DEX-treated zebrafish obtained from D3 and D7. g The gene set variation analysis (GSVA) algorithm estimates the variation in osteoblastic/osteoclastic differentiation pathway activity over that of the DEX-treated zebrafish obtained from D3 to D7. **P < 0.01, Student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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