Fig. 3
- ID
- ZDB-FIG-230120-4
- Publication
- Adane et al., 2021 - STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
- Other Figures
- All Figure Page
- Back to All Figure Page
Loss of STAG2 alters the frequency of cis-chromatin contacts (A) Volcano plot of changes in chromatin loop strength comparing STAG2 WT with KO A673 cells based on SMC1A HiChIP. EdgeR overdispersed Poisson regression, |(FC)| ≥ 2, p ≤ 0.05. (B) Pie chart depicting the fraction of differential loops involving enhancer-promoter interactions. Two-tailed Fisher’s exact test, ∗∗∗∗p < 0.0001. (C) Median + 95% confidence interval plots for lengths of differential loops. Unpaired t test with Welch’s correction, ∗∗∗∗p < 0.0001. (D) Three of the top ten enriched motifs for the enhancer regions involved in differential enhancer-promoter loops. (E) Volcano plot depicting the differential status of the 9,084 EWS/FLI1 anchored differential loops. EdgeR overdispersed Poisson regression, |FC| ≥ 2, p ≤ 0.05. (F) Pie chart depicting the fraction of EWS/FLI1 anchored differential loops involving enhancer-promoter interactions. Two-tailed Fisher’s exact test, ∗∗∗∗p < 0.0001. (G) Diagram depicting the fraction of EWS/FLI1 anchored enhancer-promoter interactions as a subset of all differential enhancer-promoter loops. Two-tailed Fisher’s exact test, ∗∗∗∗p < 0.0001. |
Reprinted from Cancer Cell, 39, Adane, B., Alexe, G., Seong, B.K.A., Lu, D., Hwang, E.E., Hnisz, D., Lareau, C.A., Ross, L., Lin, S., Dela Cruz, F.S., Richardson, M., Weintraub, A.S., Wang, S., Iniguez, A.B., Dharia, N.V., Conway, A.S., Robichaud, A.L., Tanenbaum, B., Krill-Burger, J.M., Vazquez, F., Schenone, M., Berman, J.N., Kung, A.L., Carr, S.A., Aryee, M.J., Young, R.A., Crompton, B.D., Stegmaier, K., STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma, 827-844.e10, Copyright (2021) with permission from Elsevier. Full text @ Cancer Cell