FIGURE

Figure 5

ID

ZDB-FIG-230110-140

Publication

Jim et al., 2022 - Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq

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Figure 5

Transcriptional response in pneumolysin-positive or pneumolysin-negative S. pneumoniae D39V

(A) Pneumolysin-specific transcriptional rewiring in S. pneumoniae in response to injection in zebrafish embryo. Fold change of transcriptional response in S. pneumoniae PLY+ and PLY− is plotted against its genomic location.

(B) Fold change of ComX regulons between S. pneumoniae PLY+ and S. pneumoniae PLY− strains shows gene expression regulation in response to zebrafish infection. ssbB, a member of the regulon shows increased expression in S. pneumoniae PLY+ compared with S. pneumoniae PLY− (FC ≥ 2.0, q < 0.5). Regulons are sorted by fold change value in descending order.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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