Figure 5
Transcriptional response in pneumolysin-positive or pneumolysin-negative S. pneumoniae D39V
(A) Pneumolysin-specific transcriptional rewiring in S. pneumoniae in response to injection in zebrafish embryo. Fold change of transcriptional response in S. pneumoniae PLY+ and PLY? is plotted against its genomic location.
(B) Fold change of ComX regulons between S. pneumoniae PLY+ and S. pneumoniae PLY? strains shows gene expression regulation in response to zebrafish infection. ssbB, a member of the regulon shows increased expression in S. pneumoniae PLY+ compared with S. pneumoniae PLY? (FC ? 2.0, q < 0.5). Regulons are sorted by fold change value in descending order.