FIGURE

Fig. 9

ID

ZDB-FIG-221226-312

Publication

Saettele et al., 2022 - Prolonged Dexamethasone Exposure Enhances Zebrafish Lateral-Line Regeneration But Disrupts Mitochondrial Homeostasis and Hair Cell Function

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Fig. 9

Dexamethasone exposure increased hair cell sensitivity to neomycin.A–J Representative maximum intensity images of fixed pLL neuromasts with DAPI-labeled hair cell nuclei (blue). Larvae (7 dpf) were exposed for 48 h to DMSO (carrier) alone (A–E) or dexamethasone (F–J), then exposed for 30 min or 10 µM (B, G), 30 µM (C, H), 50 µM (D, I), or 100 µM (E, J) neomycin. EM buffer alone was used as a control (A, F). K Dose–response curve with mean and SEM bars shows the number of hair cells per neuromast as a percent of those present in unlesioned controls. Dexamethasone-treated neuromast hair cells were more sensitive to neomycin-induced cell death than controls (adjusted *P < 0.05 (50 µM), ****P < 0.0001 (100 µM)). N = 7 fish per condition per trial; 3 experimental trials

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Assoc. Res. Otolaryngol.