FIGURE

Fig. 2

ID

ZDB-FIG-221226-145

Publication

Liu et al., 2022 - Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome

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Fig. 2

a Gene Ontology (GO)-based enrichment analysis of regulated protein phosphorylation sites on the ontology of biological processes, cellular components, and molecular functions. b The quantified phosphorylation sites of β-catenin and Hsp90ab1 were detected by phosphoproteome analysis in DYRK1A-overexpressed embryos. c Regulation of phosphorylation sites of β-catenin and Hsp90ab1 was verified using western blot assay in zebrafish embryos. d Whole-mount immunostaining of β-catenin at the 512-cell stage showed that nuclear β-catenin increased in the DYRK1A-overexpressed embryo. Whole embryos were flattened and viewed from the animal pole by confocal microscopy. e DS embryo model blocks Smad2/3 phosphorylation detected by western blot. f DYRK1A enhanced the expression of the Wnt reporter TopFlash in HEK-293T cells. (g) DYRK1A decreased TGF-β induced SBE-luc activity in HEK-293T cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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