FIGURE

Fig. 1

ID

ZDB-FIG-221226-144

Publication

Liu et al., 2022 - Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome

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Fig. 1

a Morphogenesis of live control (injection with GFP mRNA) and DYRK1A-overexpressed (injection with DYRK1A mRNA) embryos. The arrowheads indicate the dorsal side of the embryo. b Fusion of eyes caused by DYRK1A overexpression resembled the phenotype of lefty1 mRNA injection. c Germ layer marker expression detected by WISH during gastrulation. Orientation: ntla, sox17, and otx2, dorsal views with an animal pole to the top; others, animal-pole views with dorsal to the right. The numbers indicated in each picture are the number (left) of affected embryos with a phenotype similar to what is shown in the picture and the total number (right) of observed embryos. The same number labeling was used thereafter.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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