FIGURE
Fig. 8
- ID
- ZDB-FIG-221220-32
- Publication
- Wang et al., 2022 - Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
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Fig. 8
Overview of wfs1b Deficiency-Mediated ER Stress Inhibits M-cell Axon Regeneration. The wfs1b knockout impeded the M-cell axon regeneration due to increased ER stress, resulting in up-regulated mRNA expression of the UPR pathway. The ER stress activator TM inhibited M-cell axon regeneration in wfs1b+/+ zebrafish larvae, whereas both the application of ER stress inhibitor 4-PBA and complementation of wfs1b at the single-cell level ameliorated the degenerated M-cell axon in wfs1b−/− zebrafish larvae |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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Full text @ Acta Neuropathol Commun