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Figure 6

ID

ZDB-FIG-221214-87

Publication

Wang et al., 2022 - Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity

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Figure 6

Deficiency of SMYD3 alleviates ROS accumulation. A and B, intracellular ROS levels in Smyd3-deficient or wildtype MEF cells (Smyd3^−/− or Smyd3^+/+) under normoxia or hypoxia detected by flow cytometry analysis. Data show mean ± SD; Student’s two-tailed t test. ∗∗∗∗p < 0.0001. Data from three independent experiments. C and D, mitochondrial ROS levels in Smyd3-deficient or wildtype MEF cells (Smyd3^−/− or Smyd3^+/+) under normoxia or hypoxia detected by flow cytometry analysis. Data show mean + SD; Student’s two tailed t test. ∗∗∗∗p < 0.0001. Data from three independent experiments. HIF, hypoxia-inducible factor; MEF, mouse embryonic fibroblast; ROS, reactive oxygen species.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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