FIGURE

FIGURE 5

ID

ZDB-FIG-221211-129

Publication

Barker et al., 2022 - Fmrp regulates neuronal balance in embryonic motor circuit formation

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FIGURE 5

Surplus ventrolateral GABAergic neurons in fmr1 embryos are specified in the pMN progenitor domain. At 24 h post-fertilization, there are two populations of pMN-derived GABA⁺olig2⁺ cells in the ventral spinal cord, as shown through immunohistochemistry for gamma-aminobutyric acid (GABA) on transverse trunk spinal cord sections of Tg(olig2:EGFP) embryos: dorsal KA INs [yellow asterisks, (A?,A?,B?,B?)] and ventral lateral descending (VeLD) INs [cyan and magenta arrowheads, (A,A?,B,B?)]. Quantification of KA INs [(C); Mann?Whitney test] and VeLD INs [(D); two-tailed t-test] in wild-type and fmr1 embryos. Quantification reflects the average number of cells per section, averaged by embryo. Scale bar = 10 ?m. P-values indicated in graphs, where p < 0.05 is considered significant.

Expression Data

Gene:	GFP
Fish:	fmr1^{hu2787/hu2787}; vu12Tg/vu12Tg
Anatomical Terms:	Kolmer-Agduhr neuron spinal cord GABAergic neuron
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fmr1^{hu2787/hu2787}; vu12Tg/vu12Tg
Observed In:	spinal cord GABAergic neuron
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.