FIGURE

Fig. 3

ID

ZDB-FIG-221123-33

Publication

Sarvari et al., 2021 - The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish

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Fig. 3

The endocardium is affected in rbx1 mutants

(A-H′) 3D Confocal images (maximum intensity projections) (A–H), and 2D mid-sagittal sections (A′-H′) of the endocardium from rbx1 animals. (A-F′) Endocardial morphology in rbx1^+/+ and rbx1^−/− siblings at 60 (A-B′), 72 (C-D′) and 80 (E-F′) hpf. At 72 hpf a minor reduction in ventricular size is visible in rbx1 mutants (C-D′). At 80 hpf, rbx1 mutants exhibit a smaller ventricle with a stretched AV canal and outflow tract (E-F′). (G-H′) Endocardial morphology in rbx1^+/+ (G-G′) and rbx1^−/− (H–H′) siblings at 102 hpf. rbx1^−/− larvae exhibit a smaller ventricle (H–H′) compared with rbx1^+/+ (G-G′) siblings.

Expression Data

Gene:	EGFP
Fish:	ci1Tg rbx1^{bns148/bns148}; ci1Tg
Anatomical Terms:	atrial endocardium atrioventricular canal endocardium ventricular endocardium
Stage Range:	Pec-fin to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rbx1^{bns148/bns148}; ci1Tg
Observed In:	atrioventricular canal atrioventricular canal endocardium bulbus arteriosus ventricular endocardium
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 480, Sarvari, P., Rasouli, S.J., Allanki, S., Stone, O.A., Sokol, A., Graumann, J., Stainier, D.Y.R., The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish, 1-12, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.