FIGURE

Fig. 3

ID

ZDB-FIG-221123-18

Publication

Fowler et al., 2021 - Protein fucosylation is required for Notch dependent vascular integrity in zebrafish

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Fig. 3

Manipulation of Notch signaling affects hemorrhage rates in gmds mutant embryos. A synergistic increase in hemorrhage frequency is observed when clutches of embryos derived from gmds heterozygous matings are incubated in a low dose of DAPT (A). Overexpression of the Notch intracellular domain rescues (reduces) hemorrhage frequency in clutches derived from gmds heterozygous matings (B). Hemorrhages were quantified at 50 hpf, Chi-squared analysis with Yate's correction was used for statistical testing. Data presented as mean hemorrhage frequency across three independent experiments with error bars representing standard error of the mean.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB gmds^nfl2/nfl2 (AB)
Condition:	chemical treatment by environment: DAPT
Observed In:	brain vasculature
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 480, Fowler, G., French, D., Rose, A., Squires, P., Anecito da Silva, C., Ohata, S., Okamoto, H., French, C.R., Protein fucosylation is required for Notch dependent vascular integrity in zebrafish, 62-68, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.