FIGURE

Figure 2.

ID

ZDB-FIG-221018-169

Publication

Jimenez et al., 2022 - A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish

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Figure 2.

Cell-type-specific gene expression and expansion of HC lineage populations during regeneration

(A) Left: UMAP showing overlay of inner ear cells between non-regenerating and regenerating sensory epithelia. Colors distinguish conditions. Right: UMAP of cells across conditions grouped together based on gene expression, detecting 13 cell populations. Cluster 0 consists of SCs (SC0). Cluster 1 consists of PCs (PC1). Cluster 2 consists of HCs (HC2).

(B) Left: UMAP plots of non-regenerating and regenerating conditions side-by-side. The colors distinguish clusters labeled in (A). Middle: UMAP of 3,670 randomly sampled single cells from non-regenerating controls (pooled wild-type, untreated Tg(myo6b:hDTR), and wild-type fish injected with DT). UMAP of 3,330 randomly sampled single cells from regenerating samples on days 4, 5, and 7 post injection. Samples include saccules and utricles. Right: table and bar graph of cell numbers in non-regenerating and regenerating SCs, PCs, and HCs.

(D) Violin plots showing the distribution of gene expression of top genes identified with differential expression testing across cell types (p < 0.01; FC ≥ 0.25).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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