FIGURE

Figure 5

ID

ZDB-FIG-221018-161

Publication

Schipper et al., 2022 - Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure

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Figure 5

(A) Survival curve of zebrafish embryos infected with H44/76 expressing serogroup B capsule (1560 cfu), no capsule (HB-1) (3600 cfu), serogroup C capsule (H44/76_C) (1200 cfu), serogroup W capsule (H44/76_W) (3600 cfu) or serogroup Y capsule (H44/76_Y) (4800 cfu) all expressing mCherry 20 embryos in each group. (B) Survival of zebrafish embryos infected with H44/76 expressing serogroup B capsule (2700 ± 1820 cfu), no capsule (HB-1) (1960 ± 1420 cfu), serogroup C capsule (H44/76_C) (2160 ± 1660 cfu), serogroup W capsule (H44/76_W) (2760 ± 840 cfu) or serogroup Y capsule (H44/76_Y) (2720 ± 1817 cfu) scored at 96hpi. Three independent experiments, 20 embryos in each group. (C) Quantification of GFP-expressing neutrophils in zebrafish embryos 24 hpi with N. meningitidis H44/76_B (1400 cfu), HB-1 (1600 cfu), H44/76_C (1400 cfu), H44/76_W (4000 cfu), H44/76_Y (3000 cfu) or PBS (Mock); 11, 8, 9, 8, 7 and 8 embryos per group, respectively. IntDen = Integrated density of the green fluorescence signal in the area of interest. * P = < 0.05, ** P = < 0.01, **** P = < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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