FIGURE

FIGURE 4

ID

ZDB-FIG-221004-8

Publication

Lee et al., 2022 - A zebrafish model of congenital nephrotic syndrome of the Finnish type

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FIGURE 4

Measurement of hypoalbuminemia-like phenotype in nphs1-/- zebrafish. (A,C,E) The GFP fluorescence in wild-type siblings with Tg (l-fabp:VDBP-EGFP) at 7-9 dpf. (B,D,F) The GFP fluorescence in nphs1-/- mutants with Tg (l-fabp:VDBP-EGFP) at 7-9 dpf. (G–J) The GFP fluorescence in retina vessels and dorsal aorta of wild type fish (G,I) and of nphs1-/- mutants (H,J) at 8 dpf. (K) The quantitative measurements of the GFP fluorescence intensity in the retinal vessels (G,H) and the dorsal aorta (I–J) (arrow) using ImageJ. The error bars show the standard error of the mean (SEM) (*p ≤ 0. 1, ****p ≤ 0. 0001) (Student’s t-test).

Expression Data

Gene:	EGFP
Fish:	mi1000Tg nphs1^{mss102/mss102}; mi1000Tg nphs1^{mss103/mss103}; mi1000Tg
Anatomical Terms:	dorsal aorta blood plasma ocular blood vessel blood plasma
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nphs1^{mss102/mss102}; mi1000Tg nphs1^{mss103/mss103}; mi1000Tg
Observed In:	dorsal aorta blood plasma ocular blood vessel blood plasma renal protein absorption
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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