FIGURE

Figure 5

ID

ZDB-FIG-220901-9

Publication

Arjun et al., 2022 - Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

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Figure 5

The NG conjugates were microinjected into the aortic region of zebrafish larvae to examine the possibility of crossing the BBB in vivo via apolipoprotein receptor-mediated endocytosis. NG + PS80, NG + Rh–B, and NG + Rh–B + PS80 bright field images of microinjected zebrafish larvae (transmitted), fluorescent image (fluorescence), and grayscale + fluorescent merged image (merged). NG + PS80 and NG + Rh–B overlapped image of grayscale and red fluorescence showed no targeted delivery of NG to the CNS due to lack of fluorescence property or inability to cross BBB, respectively. The NG + Rh–B + PS80 overlapped image of grayscale and red fluorescence shows targeted delivery of NG to CNS. The yellow marked region is the spinal cord of zebrafish larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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