FIGURE

Figure 4

ID

ZDB-FIG-220901-8

Publication

Arjun et al., 2022 - Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

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Figure 4

Toxicity evaluation of NG, NG + TT, and TT in developing zebrafish (Danio rerio). (a) Control 24 hpf embryo. (b) NG treated embryos at 24 hpf had slow growth at treatments above 300 μg/ml (white arrowhead). NG + TT treated embryos at (c) 24 hpf showed slower growth in the 250 μg/ml treatment group (white arrowhead). TT treated embryos also had a developmental delay at (d) 24 hpf in the 1.2 μg/ml treatment group (white arrow head). (e) 72 hpf control fish. (f) At 72 hpf pericardial edema was observed in the 300 μg/ml NG treatment group (red arrowhead). (g) Bent tail (black arrow) was seen in 72 hpf larvae in the 1.1 μg/ml TT treatment group. (h) At 72 hpf, bent tail (black arrow), spinal kyphosis (blue arrow), and pericardial edema (red arrowhead) were observed in the 200 μg/ml NG + TT treatment group. (i) Spinal kyphosis (blue arrow) was also observed in the 1 μg/ml TT treatment group. Scale bars are 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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