FIGURE

Fig. 5

ID

ZDB-FIG-220830-20

Publication

Paulussen et al., 2022 - Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

(a) Representative pictures of uninfected and infected zebrafish larvae. Top left: Uninfected larvae. In the remaining pictures, zebrafish larvae were infected with E. coli 87 (CFU = 255) encoding fluorescent mScarlet. Subsequently, they were either treated with 17f? (c = 70 ?M), L8S1 (c = 3.125 ?M), or a combination of both. (b) Relative share of surviving zebrafish larvae after 24 h as determined by heartbeat depending on the treatment regime. (c) Effect of different treatments on the infection progress after 24 h as determined by quantification of red pixels per larvae (zebrafish larvae pictures can be found in Figure S14). All measurements were performed in quadruplicate (n = 4 replicates with 15 Zebrafish larvae per condition, error bars = SEM). Significance was determined by one-way ANOVA and Dunnet?s multiple-comparison test (*p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Am. Chem. Soc.