FIGURE

Fig. 4

ID

ZDB-FIG-220830-19

Publication

Paulussen et al., 2022 - Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex

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Fig. 4

(a) Representative fluorescent microscopy pictures (scale bar = 5 ?m) showing FtsB-mNG localization (white) in E. colilptD4213 (imp) in the presence of either DMSO, 15f?, or inhibitory peptide 17f? (both c = 100 ?M) 60 min after addition. The corresponding demograph shows the fluorescence intensity along the longitudinal axis of treated cells (cells ordered by lengths). The midcell fluorescence intensity consistent with the presence of FtsB-mNG is lost for 17f?-treated cells as indicated by the absence of a white signal at the center of the x axis compared to the others. (b) Morphology of representative E. coliLptD4213 cells treated with either DMSO or 17f? (c = 100 ?M) after 6 h (scale bar = 20 ?m). The violin plot shows the corresponding cell length distribution of samples treated with either DMSO or 100 ?M 17f? after 1 and 6 h. Significance was determined by the Kruskal?Wallis test and Dunn?s multiple-comparison test (ns: p > 0.05, ****p < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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