FIGURE

Fig. 3

ID

ZDB-FIG-220829-69

Publication

Da'as et al., 2022 - Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

Other Figures

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Fig. 3

The zebrafish mybpc3 knockout (KO) model displayed restrictive physiology of the cardiac chambers at 72 h post-fertilization (hpf). (A,B) Cardiac ventricular and (C,D) cardiac atrial analysis of the zebrafish mybpc3 KO demonstrated by the measurement of diastolic/systolic diameters that were significantly decreased in comparison to the wild-type (control) group. The number of embryos analyzed for the control = 28 and mybpc3 KO = 18. The larvae were mounted to image both chambers of the heart. Cardiac function analyses were represented in Box–Whisker plots and analysis using a one-way ANOVA multiple comparisons test. Values were expressed as the means ± SE. p values of <0.05 were considered statistically significant, a value of * p < 0.05, ** p < 0.01, and **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mybpc3^dsme1/dsme1; zf3671Tg
Observed In:	heart contraction
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.