Fig. 6

Differential kidney expressions of genes between the wild-type and Kdm4c^−/− mice. Kidney tissues of wild-type and Kdm4c^−/− mice at the age of 10 weeks were used for this study (n = 8 in each group). (A). Volcano plot showing differential kidney gene expressions between the wild-type and Kdm4c^−/− mice. The results showed that 42 genes had higher expression levels, while 46 genes had lower expression levels in the Kdm4c^−/− mice than in the wild-type mice (p-value < 0.01, q-value < 0.01). (B). The KEGG pathway analysis results showed that Kdm4c deletion was also associated with a variety of neurodegenerative diseases and metabolic diseases. (C). GO enrichment analysis showed that the Kdm4c^−/− mice had significantly different expressions in several pathways, including inner mitochondrial membrane protein complex and mitochondrial protein complex. (D). GSEA revealed that Kdm4c deletion was also associated with several pathways involved in mitochondrial function, including mitochondrial electron transport chain, oxidative phosphorylation, and mitochondrial membrane phospholipid-based signal pathways. Abbreviation: KDM4C, lysine demethylase 4C; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, gene set enrichment analysis; WT, wild-type.