FIGURE

Fig. 1

ID

ZDB-FIG-220829-238

Publication

Pan et al., 2022 - Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury

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Fig. 1

Embryo survival and kidney phenotypes of zebrafish embryos (96 untreated embryos and 96 embryos treated with kdm4c-MO injection). (A). Comparison of embryo survival rate between embryos treated with a single injection of 0.2 mM kdm4c-MO and untreated embryos (n = 96 in each group). (B). Pronephric phenotypes of zebrafish embryos after kdm4c-MO injection. Each kidney photo was taken from the dorsal view and at the developmental stage of 48 hpf of bTg(wt1b:EGFP) embryos. Compared with the untreated group, after kdm4c-MO injection, the renal tubules were tortuously dilated and the glomeruli were swollen. (C). Comparison of the defect rates of morphological phenotypes (tortuously dilated renal tubules and swollen glomeruli) of zebrafish embryos between untreated group and kdm4c-MO injection group. (D). Results of Western blotting for Kdm4c with zebrafish embryo kidneys with or without kdm4c-MO injection. Abbreviation: KDM4C, Lysine demethylase 4C; MO, morpholino oligonucleotides.

Expression Data

Gene:	EGFP
Fish:	li1Tg li1Tg + MO2-kdm4c
Knockdown Reagent:	MO2-kdm4c
Anatomical Terms:	pronephric glomerulus pronephric proximal convoluted tubule
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	li1Tg + MO2-kdm4c
Knockdown Reagent:	MO2-kdm4c
Observed In:	pronephric glomerulus pronephric proximal convoluted tubule whole organism
Stage Range:	75%-epiboly to Day 4

Phenotype Detail

Acknowledgments

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