FIGURE

Fig. 5

ID

ZDB-FIG-220812-52

Publication

Dong et al., 2022 - VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion

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Fig. 5

Zebrafish and primary mouse cortical neurons-derived EVs could partially rescue the angiogenesis of CtAs in vps28 mutants

(A and B) Characterization of zebrafish-derived EVs by TEM and NTA in 54 hpf larvae. The arrowhead represents the classical EVs.

(C) Zebrafish embryos-derived EVs microinjected into the CCV of zebrafish embryos could alleviate the CtAs defect in vps28 mutants at 54 hpf.

(D) Graphical representations of the CtAs numbers in (C).

(E and F) Characterization of primary mouse cortical neurons derived EVs by TEM. The arrowhead represents the EVs.

(G and H) Primary mouse cortical neurons-derived EVs microinjected into the CCV of zebrafish embryos could rescue the development of CtAs (G) and reduce the neurovascular DAPI leakage (H) in 54 hpf larvae. Data are represented as mean +/− SD. ∗p < 0.05.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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