FIGURE

Fig. 2

ID

ZDB-FIG-220812-31

Publication

Verwilligen et al., 2022 - Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish

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Fig. 2

Fig. 2. Absence of scavenger receptors stab1 and stab2 reduces ApoB containing lipoprotein clearance by endothelial cells.

(A–C) Uptake of lipoproteins by endothelial cells and macrophages in 3dpf ABTL and stab1^−/−stab2^−/− mpeg1:rfp transgenic zebrafish at 3 h post injection (hpi) ((ox)LDL) or 24 hpi (HDL) and the quantification of co-localization events between lipoproteins (green) and macrophages (purple) after 1 hpi (n = 9), 3 hpi (n = 6) or 24 hpi (n = 10). (D) Overview of possible mechanisms regarding cellular cholesterol uptake in ABTL and stab1^−/−stab2^−/−. Means ± SEM; p < 0.01**; p < 0.001***. Magnification: 10× and 40×. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Gene:	mCherry
Fish:	gl23Tg (AB/TL) stab1^ibl3/ibl3; stab2^ibl2/ibl2; gl23Tg (AB/TL)
Anatomical Term:	macrophage
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stab1^ibl3/ibl3; stab2^ibl2/ibl2; gl23Tg (AB/TL)
Observed In:	blood vessel endothelial cell high-density lipoprotein particle clearance blood vessel endothelial cell low-density lipoprotein particle clearance blood vessel endothelial cell oxidised low-density lipoprotein particle clearance
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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